Review Article|Articles in Press, 100098

Can probiotics reduce bipolar symptoms?: A systematic review

Published:December 09, 2022DOI:


      • Evidence suggests dysbiosis of the gut microbiome plays a role in the pathogenesis of psychiatric diseases, including bipolar disorder.
      • Preliminary studies show probiotics improve symptoms of bipolar disorder, particularly mania.
      • Probiotics are a potentially effective treatment for bipolar patients with a very limited side effect profile.



      There is growing evidence suggesting a connection between gut dysbiosis and the development of psychiatric disorders. A number of studies have shown that probiotics contribute to symptom reduction in major depressive disorder, but very few such studies have been conducted on bipolar disorder. The present study is a systematic review of such studies.


      Systematic review following PRISMA guidelines of studies published in the past ten years which involve the use of probiotics in patients with bipolar disorder.


      Of 4717 articles screened, 5 were included in this review [n = 193]. Collectively, the studies measured the effects of probiotics on the symptoms of bipolar disorder as well as rehospitalization rates.


      Despite the limited number of studies done on this topic, there is evidence that probiotics improve symptoms of bipolar disorder, particularly manic symptoms, with no significant negative effects.


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